*Please note that this Herpes News page is out of date and has not had substantive updates since 1999. However, since 2004 The Original Herpes Home Page has had a Herpes Research Summary Chart (including herpes vaccines in development) which continues to be updated on a monthly basis. Please click on the link below.
Muffin's Herpes Treatment Research Summary Spreadsheet
Herpes
Vaccines
The first vaccine to
treat a human ailment was developed in 1796 by Dr. Edward Jenner in England
who protected a child against smallpox by inoculating him with cowpox
virus. A better understanding of the human immune system has led to the
development of other vaccines which have brought under control several
major human diseases, including tetanus, polio and measles. As of
1998 only a total of 18 vaccines have proved functional
to human beings.
Vaccines to control
Herpes were first attempted in the 1950's. As of 1999, no vaccine
has proved efficacy towards Herpes.
Vaccines
now available
Just
because they are available does not mean they work. None of them are approved
for use in the US, and except for Skinner, none have had trials in the
US
The Skinner Vaccine
as developed by its
namesake GR Skinner of the U. of Birmingham, UK has undergone various trials
over the past 15 years, is available for about $ 150 in England and although
anecdotal data and open studies indicate a degree of usefulness,
the vaccine has yet to prove itself in a double blind - placebo controlled
study.
Bad link removed
Bulgarian Vaccine
- "Since 1975
over than 20,000 patients in Bulgaria have been immunized with whole herpes
vaccines with good therapeutic effect.
This study reports
on our experience with whole herpes simplex vaccines in Bulgaria for a
period of 17 years. More than1,500 immunized patients with herpes ophtalmicus
showed a reduction of the recovery period, reduced number of therecurrences
and reduced risk of visual damage. More than 14,000 patients suffering
from other forms of herpes diseases for a longer period showed reduced recovery
period and recurrence frequency in over 95% of the cases.
Bad link removed
FAILED
VACCINE
OTHER
VACCINES
These
are postings from the MAY 1999 The Herpes News
09 - Vaccines: AurX,
Inc.
AuRx has developed
a vaccine for the prevention of both fever blisters and genital herpes
which has a unique advantage over competitive products. The
AuRx vaccine has been genetically engineered to remove a potentially
ancer-provoking oncogene from the virus. This HSV-2 virus has been attenuated
to prevent the production of lesions in both infected individuals as well
as previously uninfected individuals. The company's website has several
herpes related articles, worthwhile reading
http://www.aurx.com/vaccine.htm
03 -Vaccines: Cel-Sci
Corp.
Studies with L.E.A.P.S.
(Ligand Epitope Antigen Presentation System) peptide compounds for HSV
have achieved promising in vivo results in modulating immune response.
For a HSV L.E.A.P.S. vaccine, the Company has a SBIR grant (Phase I) with
the National Institutes of Health (NIH).
http://www.cel-sci.com/leaps.htm
16 - Vaccine Ideas:
Sindbis Virus
Development of a plasmid
DNA expression vector system derived from Sindbis virus (a mosquito transmitted
virus most best known for causing horse encephalitis) indicate the
potential usefulness of alphavirus-based vectors for DNA immunization in
general and more specifically as a herpes simplex virus vaccine.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=9444987&dopt=Abstract
Vaccine
References
Emerging Herpes
Vaccines