Table of Contents
Herpesvirus infections - 1
Handouts
Overview
Herpesviruses
Herpesviruses
Herpesviruses
Genetic elements in herpes simplex virus 1.
Herpesviruses
Overview
Varicella-zoster virus (VZV)
Varicella-zoster virus (VZV)
Varicella-zoster virus (VZV)
Herpes simplex viruses: HSV-1 and HSV-2
Herpes simplex viruses: HSV-1 and HSV-2
Overview
HSV life cycle: Primary infection.
1. HSV productive infection (page 3)
1. HSV productive infection (page 3)
HSV life cycle: Establishment of latency.
LAT - ICP0: The ying and yang of HSV latency.
2. Establishment of latency.
Lymphocytes cannot “see” latent viral genomes because no viral antigens
HSV life cycle: reactivation of latent virus.
3. Reactivation of latent HSV. ICP0 triggers reactivation.
HSV life cycle: recurrent disease and viral shedding.
Subclinical HSV reactivation is more the rule than the exception
In summary: HSV goes in....
and HSV comes out…. over and over and over again.
Overview
Varicella-zoster virus (VZV)
Varicella (chickenpox)
Zoster (shingles)
Post-herpetic neuralgia is:
VZV vaccine
Overview
Herpes simplex viruses: seroprevalence versus disease
PPT Slide
Ocular herpes presents as dendritic ulcers.
Diagnosis of HSV disease
Confirming HSV diagnosis
Acyclovir-related antiviral drugs
Acyclovir-related antiviral drugs
Overview
Total number of HSV clinical cases
FACTS
What you should NOT do.
What you should DO.
Information that patients need on 1st visit.
and FINALLY…...
and FINALLY…...
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