So, I chose to get informed information from a man with a Medical Degree and PhD at Cambridge University, neuroscience degree from UCL, and the founder of The Naked Scientists Radio Show and website. Also, he is currently the clinical lecturer in Virology at Cambridge University. His name is Chris Smith (http://www.thenakedscientists.com/HTML/about-us/who-are-we/). Check out the website...I trust his opinion!Anyways...this was my question in the forum, plus his answers:
Me:
I have been doing some research on using medical grade DMSO and Acyclovir to make the herpes virus "unreactivatable". Does this sound somewhat promising?
The person would apply Acyclovir cream to the lower back (for genital herpes) and then apply DMSO (the easiest method would be to use a prediluted DMSO spray). Acyclovir is meant to disrupt the viral DNA so that it cannot replicate. But antiviral medications can only treat a herpes outbreak, not the virus itself. So, if DMSO could carry the antiviral to cells, in theory, it would be able to disrupt the viral DNA within the cell...right?
Chris:
I'm afraid that your strategy will not work because the problem of herpes reactivation is not related to a failure of aciclovir to reach the virus inside cells - aciclovir can be taken by mouth (or injected) and reaches every part of the body with good efficiency.
Instead, the problem is that the latent (quiescent or dormant) virus is not vulnerable to aciclovir. It is only once the virus has reactivated and begun replicating (usually symptomatically) that aciclovir is effective. This is because, in its native state, the drug must be activated by a viral gene product called thymidine kinase (TK), which is only made when the virus is active.
So, I'm afraid, your DMSO approach, whilst a good idea, is flawed in theory and in practice.
Me:
Okay...I have also read about using DMSO by itself or with hydrogen peroxide. Both claim that oxygenating the cells would not allow the virus to thrive (since viruses cannot live in an oxygen rich environment). Is there any truth to that theory?
Chris:
No, that theory is rubbish. The virus lives in nerve cells, which have a very high metabolic rate and hence high oxygen demand and delivery. There's no evidence for oxygen under physiological conditions killing viruses. Perhaps you're thinking of anaerobic bacteria, like Clostridia or Bacteroides, which are certainly destroyed by oxygen exposure?
*
That all makes sense to me!!!! I won't be trying the DMSO therapy now. Oh well...